Teaching University-Level Mathematics Using Mathematica

This paper considers the use of the computer algebra system Mathematica for teaching university-level mathematics subjects. Outlined are basic Mathematica concepts, connected with different mathematics areas: algebra, linear algebra, geometry, calculus and analysis, complex functions, numerical analysis and scientific computing, probability and statistics. The course “Information technologies in mathematics”, which involves the use of Mathematica, is also presented - discussed are the syllabus, aims, approaches and outcomes

Modernizing Legacy Physics Applications for Reuse in Web and SOA

This paper concerns the application of recent information technologies for creating a software system for numerical simulations in the domain of plasma physics and in particular metal vapor lasers. The presented work is connected with performing modernization of legacy physics software for reuse on the web and inside a Service-Oriented Architecture environment. Applied and described is the creation of Java front-ends of legacy C++ and FORTRAN codes. Then the transformation of some of the scientific components into web services, as well as the creation of a web interface to the legacy application, is presented. The use of the BPEL language for managing scientific workflows is also considered.* This work was partially supported by the NSF of the Bulgarian Ministry of Education and Science, project VU-MI-205/2006, and the RS-2009-M13 project of the Scientific Fund of the Paisii Hilendarski University of Plovdiv, Bulgaria

Using the Business Process Execution Language for Managing Scientific Processes

This paper describes the use of the Business Process Execution Language for Web Services (BPEL4WS/BPEL) for managing scientific workflows. This work is result of our attempt to adopt Service Oriented Architecture in order to perform Web services – based simulation of metal vapor lasers. Scientific workflows can be more demanding in their requirements than business processes. In the context of addressing these requirements, the features of the BPEL4WS specification are discussed, which is widely regarded as the de-facto standard for orchestrating Web services for business workflows. A typical use case of calculation the electric field potential and intensity distributions is discussed as an example of building a BPEL process to perform distributed simulation constructed by loosely-coupled services

Leveraging Existing Plasma Simulation Codes

This paper describes the process of wrapping existing scientific codes in the domain of plasma physics simulations through the use of the Sun’s Java Native Interface. We have created a Java front-end for a particular functionality, offered by legacy native libraries, in order to achieve reusability and interoperability without having to rewrite these libraries. The technique, introduced in this paper, includes two approaches – the one-to-one mapping for wrapping a number of native functions, and using peer classes for wrapping native data structures

SOME NOTES ON THE FAST ADAPTIVE NEURAL NETWORK SOLVERS.

With this paper, we discuss some important aspects related to the iterative solution of two classes of polynomials, nonlinear systems of equations, and the adapted to them – "FAST adaptive neural solver" (FANS). The crucial issue of choosing initial approximations (separation of unattractive networks of initial data) and the possibility of minimizing CPU–time with the use of existing FANS is discussed

Sovereign democracy, populism, and depoliticization in Russia. Power and discourse during Putin's first presidency

Legitimizing strategies used to stabilize the regime during the 2000-2008 presidency of Vladimir Putin included—from a discourse-theoretical perspective—democracy, populism, depoliticization, retraditionalization, and modernization

Dynamic trafficking and turnover of JAM-C is essential for endothelial cell migration

Junctional complexes between endothelial cells form a dynamic barrier that hinders passive diffusion of blood constituents into interstitial tissues. Remodelling of junctions is an essential process during leukocyte trafficking, vascular permeability, and angiogenesis. However, for many junctional proteins, the mechanisms of junctional remodelling have yet to be determined. Here, we used receptor mutagenesis, horseradish peroxidase (HRP), and ascorbate peroxidase 2 (APEX-2) proximity labelling, alongside light and electron microscopy (EM), to map the intracellular trafficking routes of junctional adhesion molecule-C (JAM-C). We found that JAM-C cotraffics with receptors associated with changes in permeability such as vascular endothelial cadherin (VE-Cadherin) and neuropilin (NRP)-1 and 2, but not with junctional proteins associated with the transmigration of leukocytes. Dynamic JAM-C trafficking and degradation are necessary for junctional remodelling during cell migration and angiogenesis. By identifying new potential trafficking machinery, we show that a key point of regulation is the ubiquitylation of JAM-C by the E3 ligase Casitas B-lineage lymphoma (CBL), which controls the rate of trafficking versus lysosomal degradation.TDN, CS, and KBK were funded by an MRC project grant MR/M019179/1. KBK also received funding from the People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme (FP7/2007-2013) under REA grant agreement n° 608765. AB and TPM were funded by QMUL. SN was funded by a Wellcome Trust investigator award 098291/Z/12/Z. MA was funded by Canceropôle PACA (Valo-Paca 2016) and French National Institute of Cancer (Inca, PRT-K16, #2017-24). PC and VR were funded by BBSRC (BB/M006174/1) and the Barts and The London Charity (297/2249). IJW was funded by an MRC LMCB core grant award MC_U12266B